Mitsunari Nakajima Selected Research

Flavonoids

1/2021	[The Search for Citrus Components with Neuroprotective and Anti-dementia Effects in the Mouse Brain].
4/2016	3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus.
5/2014	3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model.
10/2012	Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice.

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Mitsunari Nakajima Research Topics

Disease

11	Inflammation (Inflammations) 03/2024 - 05/2013
8	Ischemia 01/2021 - 10/2012
7	Alzheimer Disease (Alzheimer's Disease) 08/2019 - 06/2003
6	Brain Ischemia (Cerebral Ischemia) 01/2021 - 10/2012
5	Body Weight (Weight, Body) 03/2024 - 01/2014
3	Glioma (Gliomas) 03/2020 - 08/2019
3	Hyperglycemia 01/2020 - 08/2018
3	Parkinson Disease (Parkinson's Disease) 08/2019 - 10/2016
2	Reperfusion Injury 01/2020 - 07/2018
2	Demyelinating Diseases (Demyelinating Disease) 01/2016 - 11/2013
1	Glucose Intolerance 03/2024
1	Fibrosis (Cirrhosis) 03/2024
1	Nutrition Disorders (Nutritional Disorders) 03/2023
1	Frailty 03/2023
1	Type 2 Diabetes Mellitus (MODY) 01/2023
1	Sepsis (Septicemia) 01/2022
1	Asthma (Bronchial Asthma) 01/2022
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2022
1	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 01/2022
1	Disseminated Intravascular Coagulation 01/2022
1	Dizziness (Lightheadedness) 01/2022
1	Liver Diseases (Liver Disease) 01/2022
1	Neoplasms (Cancer) 05/2021
1	Infections 05/2021
1	Cognitive Dysfunction 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Neuroblastoma 03/2020
1	Brain Diseases (Brain Disorder) 12/2019
1	Central Nervous System Diseases (CNS Diseases) 08/2019
1	Epilepsy (Aura) 08/2019
1	Chronic Pain 08/2019
1	Brain Injuries (Brain Injury) 04/2019
1	Mental Disorders (Mental Disorder) 12/2016
1	Memory Disorders (Memory Loss) 04/2015
1	Stroke (Strokes) 04/2015
1	Multiple Sclerosis 11/2013
1	Neuromyelitis Optica (Devic's Disease) 11/2013
1	Neuroinflammatory Diseases 05/2013
1	Hydrocephalus (Hydrocephaly) 03/2011
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2002
1	Seizures (Absence Seizure) 08/2002

Drug/Important Bio-Agent (IBA)

10	auraptenIBA 03/2020 - 01/2013
8	LipopolysaccharidesIBA 01/2022 - 05/2013
8	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021 - 10/2012
7	Proteins (Proteins, Gene)FDA Link 03/2023 - 12/2006
7	Neuroprotective AgentsIBA 03/2020 - 01/2013
6	Presenilin-1IBA 03/2011 - 06/2003
5	PowdersIBA 01/2020 - 01/2014
4	FlavonoidsIBA 01/2021 - 10/2012
4	Messenger RNA (mRNA)IBA 03/2020 - 11/2013
4	3,3',4',5,6,7,8-heptamethoxyflavoneIBA 04/2016 - 10/2012
3	Streptozocin (Streptozotocin)FDA Link 01/2020 - 08/2018
3	naringinIBA 01/2019 - 07/2018
3	Calcium-Calmodulin-Dependent Protein KinasesIBA 07/2018 - 04/2015
2	AntioxidantsIBA 03/2023 - 04/2015
2	oenothein BIBA 05/2021 - 05/2013
2	Nerve Growth Factors (Neurotrophins)IBA 01/2021 - 10/2012
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 03/2020 - 12/2019
2	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 03/2020 - 10/2012
2	Phosphotransferases (Kinase)IBA 03/2020 - 10/2017
2	coumarinIBA 12/2019 - 01/2013
2	CuprizoneIBA 01/2016 - 11/2013
1	tipepidineIBA 03/2024
1	LipidsIBA 03/2024
1	imidazoleIBA 03/2024
1	Coffee FDA Link 01/2023
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	ibudilastIBA 01/2022
1	Plasminogen Activator Inhibitor 1IBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2022
1	Dacarbazine (DIC)FDA LinkGeneric 01/2022
1	ellagitanninIBA 05/2021
1	Ointments (Pastes)IBA 01/2021
1	glansreginin AIBA 01/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2018
1	Glutathione (Reduced Glutathione)IBA 07/2018
1	MitogensIBA 10/2017
1	U 0126 (UO 126)IBA 10/2017
1	Cholinergic Agents (Cholinergics)IBA 12/2016
1	CorticosteroneIBA 04/2016
1	FlavonesIBA 04/2015
1	flavoneIBA 04/2015
1	EdaravoneIBA 04/2015
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2014
1	CopperIBA 11/2013
1	Kcnj10 (channel)IBA 11/2013
1	Aquaporins (Water Channels)IBA 11/2013
1	Inwardly Rectifying Potassium Channels (Inward Rectifier Potassium Channels)IBA 11/2013
1	Chelating AgentsIBA 11/2013
1	AutoantibodiesIBA 11/2013
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2013
1	Intermediate Filament ProteinsIBA 10/2012
1	Glial Fibrillary Acidic ProteinIBA 10/2012
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 10/2012
1	Isoaspartic Acid (Isoaspartate)IBA 08/2002
1	Indicators and Reagents (Reagents)IBA 08/2002

Therapy/Procedure

1	Induced Hypothermia 01/2022
1	Therapeutics 04/2019
1	Oral Administration 10/2017